[6] It is the only allopatric beaded lizard species, separated from the nearest population (H. alvarezi) by 250 km (160 mi) of unsuitable habitat.

[9] The Guatemalan beaded lizard belongs to the family Helodermatidae, which forms part of a clade of reptiles with toxin-secreting glands.

Home ranges and behavior of these lizards were investigated using radiotelemetry at the dry forests of Zacapa, Guatemala.

[7][8][12] H. charlesbogerti dwells in arroyos characterized by high densities of bird nests of doves and parakeets, whose eggs form the primary component of its diet.

[13] These birds nest closer to the ground in these arroyos in trees with branches thick enough to support the weight of this heavy-bodied lizard.