However, her body begins to break down as an effect of the treatments and she grows desperate and unhinged, lashing out at first to her manager, Hiroko Tada (alias Mom) and agency and later to the public as she realizes that her current lifestyle cannot last long.

The matter is made worse when Tada introduces Liliko to Kozue Yoshikawa whose natural beauty and friendly demeanor makes her a popular fashion icon to women all around.

In an attempt to stay ahead, Liliko forces her overly stressed out assistant, Michiko Hada, and her boyfriend to sabotage Kozue.

Meanwhile, an inspector investigating a series of mysterious suicides and organ theft believes that Liliko and her unnatural beauty may be the key to unearthing an underground industry of unsafe medical practice and save lives.

Later on, Tada has a talk with the makeup artist who had long worked for her agency and Kozue learns Liliko's dark secret in having plastic surgery.

Later, she celebrates the end of the shoot by going to a club notable for its "strange shows" and sees Liliko about to perform, wearing an eyepatch over her left eye.

Helter Skelter won an award of excellence at the Japan Media Arts Festival sponsored by the Japanese government in 2004.