[2][3] Setiawan had also played in the mixed doubles discipline, and his best result was in 2010 Indonesia Open, finishing as runner-ups with his partner Anastasia Russkikh from Russia.

[11] Setiawan began his international journey at the 2001 Asian Junior Championships, where he won the bronze medals in the boys' team and mixed doubles events.

[18] Setiawan reached his first IBF Grand Prix finals in the 2004 Denmark Open, but he and Kido were defeated by the home pairing of Lars Paaske and Jonas Rasmussen in straight games.

[39][40] They also reached semi-finals in the Macau and Denmark Opens, but they were defeated by Malaysian pair Koo Kien Keat and Tan Boon Heong in both tournaments.

[41][42] Setiawan and Kido had never won a single match to Koo and Tan since their first meeting in January 2007 at the Malaysia Open, and the head-to-head record between the pairs stood at 0–4.

[45] Setiawan then won his second men's doubles gold medal at the Games with Kido, defeating Hendri Saputra and Hendra Wijaya in the final.

In the final, Setiawan and Kido won the gold medal, beating the home pair of Cai Yun and Fu Haifeng in three games, 12–21, 21–11, 21–16.

[54][55][56] Their tournament streak came to an end when they lost to arch-rivals Koo Kien Keat and Tan Boon Heong in the quarter-finals of the Hong Kong Open.

[72] Prior to the SEA Games, Setiawan and Kido had submitted their resignation letters to Badminton Association of Indonesia, and chose to train at their club, Jaya Raya Jakarta.

[81] Setiawan and Russkikh then started to gain traction after reaching the finals of the Indonesia Open, but they failed to win the title after being defeated by the Polish pair of Robert Mateusiak and Nadieżda Zięba.

[83] Setiawan and Kido competed at the BWF World Championships in Paris, and won a bronze medal after being defeated by Cai Yun and Fu Haifeng in the semi-finals.

[88] Setiawan and Kido later won the gold medal in the 2010 Asian Games in Guangzhou, China after beating Koo Kien Keat and Tan Boon Heong.

[97] In the men's doubles event however, Setiawan and Kido failed to defend their title, winning a silver medal after losing to Mohammad Ahsan and Bona Septano in the final.

Setiawan and Marissa started their debut in Europe tour in February–March, but gave undesiring results after losing in the early rounds at the German, All England and Swiss Opens.

At the Thomas Cup, Setiawan and Ahsan won their first match against Lee Yong-dae and Yoo Yeon-seong, leading Indonesia to a 3–2 win in the quarter-finals tie against South Korea.

[127] They later played at an invitational tournament, named "Glory to the King", and won the men's doubles title after beating the home pair of Bodin Isara and Pakkawat Vilailak in the final.

[144] He first paired with Rian Agung Saputro to compete at the Indonesia Masters, but the duo were defeated by their compatriots Marcus Fernaldi Gideon and Kevin Sanjaya Sukamuljo in the second round.

[148] To collect BWF ranking points, Setiawan and Ahsan participated at the lower-graded Malaysia International Challenge, and emerged victorious after defeating the home pair of Aaron Chia and Soh Wooi Yik in the final.

[157] Setiawan and Ahsan captured their second World Tour title of the year at the New Zealand Open when they beat Japanese pairing of Hiroyuki Endo and Yuta Watanabe in the final in a close rubber game.

The final was held on Setiawan's birthday, making him the oldest player to have won a World Championships title at the age of 35 years and 0 days.

[165] At the end of the year, Setiawan and Ahsan defeated Hiroyuki Endo and Yuta Watanabe, 24–22, 21–19 in straight games to win the BWF World Tour Finals.

Competing with Mohammad Ahsan as the 2nd seeds, he finished fourth after being defeated by Malaysia's Aaron Chia and Soh Wooi Yik in the bronze medal match.

[184] In the next tournament the following week, Ahsan and Setiawan lost in the first round of India Open to the unseeded Chinese pair Liang Weikeng and Wang Chang.

[185] After, in their home tournament, Indonesia Masters, Ahsan and Setiawan lost in the second round, losing to fellow Indonesians Leo Rolly Carnando and Daniel Marthin, the eventual champions.

[187] In late April, Setiawan competed at the Asian Championships in Dubai, United Arab Emirates, but had to lose in the quarter-finals from 6th seed and eventual champion Indian pair Satwiksairaj Rankireddy and Chirag Shetty.

[190] In the next tour, they competed at the home tournament, Indonesia Open, but lost in the second round from their compatriot Indonesian pair Pramudya Kusumawardana and Yeremia Rambitan in rubber games.

[191] In July, Setiawan competed at the Canada Open, but lost in the quarter-finals from 5th seed Chinese Taipei pair Lee Yang and Wang Chi-lin.

[192] In the East Asian Tour, he competed at the Japan Open, but lost in the quarter-finals against 1st seed fellow Indonesian pair Fajar Alfian and Muhammad Rian Ardianto for second times this year.

[193] In early August, Setiawan competed at the Australian Open, but had to lose in the second round from Taiwanese pair Lu Ching-yao and Yang Po-han in straight games.

[194] In late August, he competed at the World Championships, but lost in the quarter-finals round from 9th seed Korean pair Kang Min-hyuk and Seo Seung-jae in straight games.