Its administrative centre is located in the city of Henichesk.

[2] On 18 July 2020, as part of the administrative reform of Ukraine, the number of raions of Kherson Oblast was reduced from 18 to five, and the area of Henichesk Raion was significantly expanded.

[3][4] The January 2020 estimate of the raion population was 58,331 (2020 est.).

[6][7] Because de jure they were not allowed to return to their Crimea homeland, some Tatars settled in nearby places, including Henichesk Raion.

[6] During the 2022 Russian invasion of Ukraine, the raion was captured and occupied by Russia.