[1] In 2016 he recorded five top-5 finishes, including a tie for second at Vodacom Origins of Golf at Wild Coast Sun, behind Madalitso Muthiya.

At the 2021 installment, which lost European Tour co-sanctioning as a result of COVID-19 related travel restrictions, he finished solo 3rd, which helped him break into the top-200 on the Official World Golf Ranking for the first time.

[4] Du Plessis played on the 2021 Challenge Tour, where he lost a four-way playoff at the Limpopo Championship to Brandon Stone.

He came close to a first European Tour victory in wire-to-wire style when he took a two-shot lead into the final round of the MyGolfLife Open in South Africa.

[6] Du Plessis finished runner-up at the 2022 LIV Golf Invitational London, a single stroke behind his compatriot Charl Schwartzel, to collect a US$2,125,000 check.