Henri-François Gautrin (born July 30, 1943 in Béthune, France) is a Quebec politician, professor and physicist.

He was the Member of National Assembly of Quebec for the riding of Verdun in the Montreal region.

Gautrin went to Collège Stanislas before going to the Université de Montréal where he obtained a bachelor's degree in sciences.

He was also active in politics as the leader of the New Democratic Party of Quebec from 1973 to 1979 and was the president of the NO committee in the Taillon riding in the 1980 referendum.

When the Liberals returned to power in 2003, Gautrin was named the Parliamentary secretary to Premier Jean Charest from 2003 to 2005.