Cinq-Mars was the son of Marshal Antoine Coiffier de Ruzé, marquis d'Effiat, a close friend of Cardinal Richelieu, who took the boy under his protection on his father's death in 1632.
As the son of the marquis d'Effiat, a famous Superintendent of Finances who was also a good friend of Richelieu's, Cinq-Mars came to court very early.
Consequently, Richelieu had Cinq-Mars imprisoned and beheaded in the Place des Terreaux in Lyon, along with his accomplice, François Auguste de Thou.
Barbara Strozzi composed a cantata about the execution of the marquis ("Il lamento sul Rodano severo").
A famous historical painting by Paul Delaroche shows Cardinal Richelieu in a gorgeous barge, preceding the boat carrying Cinq-Mars and De Thou to their execution.