He gave lectures with the Royal Academy of Medicine in Paris, and practiced surgery at Hôpital de la Charité.
Le Dran made contributions in his pioneer research of cancer, and his work involving military surgery.
He advocated surgery for cancer before the tumor was allowed to metastasize through the lymphatic system and affect other parts of the body.
[2] He is widely credited for introducing the medical term "shock" (choquer), which he defined in a treatise on gunshot wounds as a sudden impact or jolt.
[3] Among his written works was a 1749 surgical treatise called Traité des opérations de chirurgie, being later translated into English and published as "The Operations in Surgery".