Probably to be near her son (who had been placed in the care of a banker's family), Henriette Amalie acquired a large house in Bockenheim, later named the "Villa Passavant," then built the former Franck-school and finally the current Saint Elisabeth's hospital.
She pursued extensive agriculture activities and made the estate virtually self-sufficient.
She introduced silkworm (Bombyx mori) breeding, kept bees, and sold oranges from her own residence.
In Kreuznach she acquired the feudal estate (German: Rittergut) of Bangert and established there a small castle (today a public museum) in the classicist style to replace the old manor house; it was completed about 1775.
Around this time her son died at approximately 30 years of age, a victim of consumption.