Born and raised in Örnsköldsvik, Sweden, Sedin and his identical twin brother Daniel played together throughout their careers; the pair were renowned for their effectiveness as a tandem.

[2] He was also named to the NHL first All-Star team that year and again in 2010–11, a season that included an appearance in the Stanley Cup Finals, where Vancouver lost to the Boston Bruins in seven games.

[5] Their agent, Mike Barnett, president of international talent agency IMG, presented them with two options to circumvent the usual NHL draft process, allowing them to play together.

[38] His breakout season was sparked, in part, by the signing of winger Anson Carter, who played on the Sedins' line and led the team in goal-scoring.

[38] Vancouver's head coach at the time, Marc Crawford, recalled that season as marking the Sedins' ascent as leaders on the team, stating, "By the end of that year, they definitely were our top guys.

Winger Taylor Pyatt, who had been acquired in a trade from the Buffalo Sabres during the off-season, replaced Carter as the Sedins' linemate[41] and went on to score a career-high 23 goals.

[43] He struggled to produce offensively in his 12 games in the playoffs, however, managing four points as the Canucks were eliminated by the eventual Stanley Cup champion Anaheim Ducks in the second round.

[51] Bernier was later removed;[52] on 12 February 2009, Canucks head coach Alain Vigneault moved Alexandre Burrows to the line during a game against the Phoenix Coyotes.

[55] Set to become unrestricted free agents on 1 July 2009, Henrik and Daniel began negotiating with the Canucks in the off-season and were reported to have asked for 12-year, $63 million contracts in mid-June.

[56] With free agency looming, Canucks general manager Mike Gillis travelled to Sweden to visit the Sedins, where they agreed on identical five-year, $30.5 million contracts on 1 July.

[62] On 7 January 2010, Henrik moved into top spot in the NHL scoring race, ahead of San Jose Sharks centre Joe Thornton with a three-assist night against the Phoenix Coyotes for all three assists on goals by Alexandre Burrows.

It marked the first time in nearly five years, since Näslund was tied with Robert Lang on 18 February 2004, that a Canucks player held the League lead in scoring.

[63] During a 3–1 win against the Calgary Flames on 14 March, Henrik recorded his 416th career assist on a goal scored by Daniel to pass Trevor Linden as Vancouver's all-time leader.

[64] On 27 March, he scored two assists on goals by Aleaxandre Burrows and Daniel against the San Jose Sharks to become the fourth Canuck in team history to record a 100-point season (after Pavel Bure, Alexander Mogilny and Markus Näslund).

[67] Henrik entered the final game of the regular season, on 10 April against the Calgary Flames, one point behind Washington Capitals forward and captain Alexander Ovechkin for the NHL scoring lead.

[68] Ovechkin failed to register a point in his last game the next day against the Boston Bruins, earning Henrik the League scoring title and making him the first Art Ross Trophy winner in Canucks history.

(Chicago Blackhawks forwards Doug and Max Bentley also won separate scoring titles, but had achieved the feat three years apart in 1943 and 1946, respectively.

His first three assists helped the Canucks set another team record for the fastest three goals scored in a playoff game; all three were registered on 5-on-3 powerplays in a span of one minute and fifty-five seconds.

[86][87] With San Jose facing elimination the following game, Henrik recorded two more assists on goals by Burrows and Kesler for his 11th and 12th points in the series, tying Bure for most in a single round by a Canucks player.

For his regular season efforts, Henrik was named to the NHL first All-Star team for a second consecutive year, alongside Daniel, who earned the distinction for the first time.

He briefly left the game and while a subsequent CT scan revealed no fracture, he remained questionable for the following contest before eventually playing through the ailment.

[101][notes 3] Near the end of the regular season on 21 March, Daniel sustained a concussion during a game against the Chicago Blackhawks, forcing Henrik to play without his brother for the final nine contests of the campaign.

[105][106] The season-ending streak helped the Canucks to their second consecutive Presidents' Trophy, clinching the championship on the last game of the campaign on 7 April, a 3–0 win against the Edmonton Oilers.

[104] With 67 assists, he led the League for a third consecutive season, becoming the fifth player in NHL history to do so, after Joe Thornton (2005–08), Wayne Gretzky (1979–92), Bobby Orr (1969–72) and Stan Mikita (1964–67).

[115] Despite another lockout beginning on 15 September 2012, the Sedins decided that they would only return to Modo, now managed by former teammate Markus Näslund, if the entire 2012–13 season wound up cancelled.

During a commercial break, the Canucks ran a tribute video for the accomplishment, featuring congratulations from Näslund and Trevor Linden, the third-leading scorer in team history.

[117] In the final game of the season against the Edmonton Oilers on 27 April, Canucks head coach Alain Vigneault wanted to rest his regulars ahead of the playoffs.

[141] On 22 June 2021, it was announced that Henrik and Daniel would join the Canucks Hockey Operations department and were named special advisors to the general manager.

His increased tendency to shoot was given an extra push when Daniel suffered the first major injury of his career early in the 2009–10 season, forcing Henrik to play without his brother for several weeks and consequently pass less often.

Canucks then-general manager Brian Burke publicly complained, commenting during a 2002 playoff series against the Detroit Red Wings, "'Sedin' is not Swedish for 'punch me or headlock me in a scrum'.