Henry Brewer Metcalf (April 2, 1829 – October 5, 1904) was an American prohibitionist and politician from Rhode Island, who served as the Prohibition Party's gubernatorial candidate thrice and vice presidential nominee in 1900.

Henry Brewer Metcalf was born in Boston, Massachusetts on April 2, 1829, and attended public schools in the city.

When he was 15 he was apprenticed to a dry goods importing and jobbing company in Boston to aid his family's finances.

He later formed the Campbell Machine Company in Boston which made machinery to make shoes.

In 1904, he was selected to be the Prohibition Party's gubernatorial candidate again, but he died in Pawtucket, Rhode Island on October 5, 1904, after suffering a series of strokes at the age of 75 and was replaced by William E.