[5] Fambrough was drafted into the U.S. Army in 1961 and on his return two years later, the Spinners signed up under Motown Records.

[6][7] They did not have any big hits for the next six years, and Fambrough ended up working as a chauffeur for the mother of label boss Berry Gordy Jr.[8][9] During the group's heyday from the early to mid-1970s, Henry served as one of the group's three lead singers (along with Philippé Wynne and Bobby Smith)[4] and his rich baritone provided lead vocals for the Spinners classic "I Don't Want to Lose You",[10][11][12] as well as co-lead vocals with Wynne on "Living a Little, Laughing a Little".

[13] On the group's classic single "Ghetto Child", he shared leads with Wynne and Smith.

[14] In April 2023, Fambrough announced his retirement, but the Spinners continued to perform without him, and he remained involved with the group behind the scenes.

His funeral was held in a Detroit church where he was a long-time member and he was interred in Woodlawn Cemetery on the city's north side.