Henry Guthrie (c. 1600 – 1676) was a 17th-century Scottish historian and cleric who rose to be Bishop of Dunkeld.
The son of Elizabeth Small and the Perthshire minister Henry Guthrie, he was born around 1600 in Coupar Angus, a town in central Scotland, in the modern region of Perth and Kinross.
He graduated from the University of St Andrews in 1621, studying theology.
He became minister of Guthrie in 1624, and was promoted by the King Charles I to the Church of the Holy Rude, Stirling in 1632.
Despite once opposing the re-establishment of episcopacy, abandoned since the National Covenant of 1638, he changed his position, and later after the episcopate of George Haliburton, became Bishop of Dunkeld, to which position he was consecrated on 24 August 1665.