Henry II was a member of the Münsterberg line of the Bohemian noble Poděbrady family.

After his father's death in 1536, Henry initially ruled Münsterberg-Oels jointly with his brothers Joachim, John and George II.

In a joint deed dated 25 June 1535, they awarded the city of Srebrna Góra (Silberberg), which belonged to Münsterberg, the status of free mining town.

In 1537, they expelled the Catholic priests from Münsterberg (Ziębice) and appointed an evangelical vicar.

In 1542, Henry and his brothers pledged the heavily indebted Duchy of Münsterberg to their uncle Duke Frederick II of Legnica.