Henry John Cambie (October 25, 1836 – April 23, 1928) was a Canadian surveyor and civil engineer and a notable figure in the completion of Canada's transcontinental railway.

With the Confederation of Canada in 1867, the CPR was contracted to build a transcontinental railway, which would link the new country and the adjacent colonies and territories of British North America.

In that capacity, Cambie argued for a route through the Fraser Canyon and terminating at the small logging community of Granville on Burrard Inlet.

He was convinced of the superiority of that route over the alternatives of Howe Sound and Bute Inlet after a trip down the canyon to Granville in 1874.

In this and other developments, Cambie's connections with the CPR — and especially, its president, William Van Horne — were crucial to his success, since the company owned much of the land around Vancouver.