In 1689 he married Mary Kemp (1664-1754), the daughter of Anthony Kemp of Slindon in Sussex and with her had three sons: Henry, Henry-John and John, who all died unmarried[2][3][4] and three daughters: Mary Agnes Tichborne (1695–1777) who married Michael Blount (1693–1739);[5] Mabella Tichborne (1708–1727), who married Sir John Webb; and Frances Cecily Tichborne (1691–1763), who married George Brownlow Doughty.
[3] He died in July 1743 in Tichborne, Hampshire without surviving male issue[6] and was buried with his family in the church of St Andrew in the village.
In his will, he left the manor at Leckford to his two surviving daughters: Mary Blount, by now a widow, and Frances Brownlow Doughty.
[7] His younger brother Sir John Hermengil Tichborne, a Jesuit priest, succeeded to the title as the 5th Baronet.
He died without a male heir on 5 May 1748 at Ghent, Belgium[8]