Sir Henry Pollexfen (1632 – 15 June 1691) of Nutwell in the parish of Woodbury, Devon, was Lord Chief Justice of the Common Pleas.

In 1674 he became a bencher at Inner Temple, and was the leading practitioner on the western circuit, frequently pleading at the King's Bench.

He frequently acted as counsel in various politically charged cases, and regularly lost; clients included the lords involved in the Popish Plot, the Earl of Danby and as one of many counsel for Edward Fitzharris, Stephen College and Algernon Sidney, all of whom were later executed.

In 1688 he was made a justice, and advised the House of Lords on the legality of Quo warranto seizures.

In 1664, aged 32, he married Mary Duncombe, a daughter of George Duncombe (d.1677) of Weston in the parish of Albury[5][6] and of Shalford in Surrey, and sister of Sir Francis Duncombe, 1st Baronet (died 1670) of Tangley Park in Surrey,[7] by whom he had issue one son (who died childless) and four daughters as follows:[8] After serving as Chief Justice for two years Pollexfen died of a burst blood vessel at his home in Lincoln's Inn Fields on 15 June 1691.