He is a co-founder of Broadcom Corporation, owner of the Anaheim Ducks of the National Hockey League (NHL), and a prominent philanthropist in the Orange County, California, community.

He is a Fellow of the Institute of Electrical and Electronics Engineers (IEEE) for contributions to VLSI architectures and realizations for high-bit rate digital communication systems.

He was also elected a member of the National Academy of Engineering (NAE) in 2003 for pioneering contributions to academic research and technology entrepreneurship in the broadband communications system-on-a-chip industry.

In 2012 Samueli won the Marconi Prize and Fellowship for "pioneering advances in the development and commercialization of analog and mixed signal circuits for modern communication systems, in particular the cable modem.

Samueli's parents, Sala and Aron, were Polish-Jewish immigrants who survived the German Nazi occupation of Europe and arrived in the United States with almost nothing.

Samueli still remains on leave from UCLA and he continues to be listed on the Electrical and Computer Engineering Department faculty roster.

In 2009 Henry Samueli was a founding director of the Broadcom Foundation, a 501c(3) corporate nonprofit, and he is the chair of this philanthropy that advances science, technology, engineering and math (STEM).

[28] During the technology boom in the 2000s, Samueli and Broadcom co-founder Henry T. Nicholas III awarded millions of stock options to attract and reward employees.

Prosecutors alleged Samueli and Nicholas granted options to others, including some other top executives, but not themselves, to avoid having to report $2.2 billion in compensation costs to shareholders.

[29] On May 15, 2008, Samueli resigned as chairman of the board and took a leave of absence as Chief Technology Officer after being named in a civil complaint by the SEC.

Under the plea bargain, Samueli agreed to a sentence of five years probation, a $250,000 criminal fine, and a $12 million payment to the US Treasury.

[31] In his ruling Judge Carney stated,The uncontroverted evidence at trial established that Dr. Samueli was a brilliant engineer and a man of incredible integrity.

[32]In the ruling, Judge Carney went on, "Needless to say, the government’s treatment of Dr. Samueli was shameful and contrary to American values of decency and justice."