The station building was built between 1845 and 1846 after a design by Georg Moller in the neo-classical style on the town side, to the east of the line.

The facade of the lower level of the two-story sandstone building is marked on the long side by five bays, the central group of three on the ground floor act as entrances to the vestibule.

The building is listed by the Hessian heritage office as an early railway station of outstanding historical significance.

[6] Heppenheim station was modernised and equipped for the disabled in preparation for Hessentag (a festival devised to promote unity in the state of Hesse, which was created in 1945) in the summer of 2004.

In the station area there are still a number of shunting and freight tracks, which connected to the premises of different companies, but they are now overgrown and were finally dismantled in mid-2015.