To date, this version of the song has been the biggest commercial success, spending twelve consecutive weeks on the US Billboard Hot 100 chart, peaking at number 15.

The most notable cover version is a duet by Charles and Norah Jones, which appeared on the 2004 album Genius Loves Company.

Although its two most successful versions have been rhythm and blues recordings, many of its other notable covers were featured on country music albums.

[1] According to Will Friedwald in A Biographical Guide to the Great Jazz and Pop Singers, "His first four ABC albums were all primarily devoted to standards..."[2] In the 1960s, he experienced crossover success with both rhythm and blues and country music.

Because Charles was signed to ABC as a rhythm and blues singer, he decided to wait until his contract was up for its three-year renewal before experimenting with country music, although he wanted to do so sooner.

[7] Thus, "Here We Go Again" was a country music song released by the Tangerine label ABC-Paramount, but performed in Charles' rhythm and blues style.

[10] First released by Charles in 1967, "Here We Go Again" was written by Don Lanier and Rod Steagall and published by the Dirk Music Company.

[37] According to Will Friedwald, this song is an example of Charles vocalizing in what would ordinarily be a generally extraneous manner for dramatic effect by using a different voice than he had ever previously exhibited.

[42] The cover, which according to programming guides had an easy listening and country music appeal,[43] was produced by Billy Strange.

[45][46] Billboard magazine staff reviewed the song favorably, stating that the cover was a "smooth sing-a-long pop style".

[58][59] According to AllMusic databases, 1969 was the final year in her career that Sinatra reached the Hot 100 chart (with "Here We Go Again", "God Knows I Love You" and "Drummer Man").

"[65] She noted in one ...Featuring interview that the only part that was not done live was a piano overlay that she added afterwards to complement Charles' keyboard.

[66] On the record, the two singers vocalize,[67] accompanied by Billy Preston on Hammond organ,[68][69] who had at one time been the regular organist in Charles' band.

[73] The song was described by the Orlando Sentinel's Jim Abbott as a recreation of one of the gems from Charles' country music phase of the 1960s that produced the perfect "combination of voices and instruments" with Preston's accompanying role on Hammond B3.

[7] As opposed to other tracks on the album, when Charles' voice was understated, this song was said to represent his "indomitable spirit", while Jones performed as "an empathetic foil, [with] her warm, lazy vocals meshing convivially with his over a spare but funky arrangement".

[64] Author Mike Evans wrote that "there's a mutual warmth of purpose in every breath [Charles and Jones] take" on the song.

[68] Music Week staff noted the timeliness of the release with the biographical film Ray in theaters and described the song as soulful, that finely combines Charles' "deep, honeyed growl with Jones's lighter timber", while noting Preston for his "sweeping" organ work.

Robert Christgau notes that Jones carried the vocal burden as did many of Charles's duet partners on the album.

[64] Critic Randy Lewis from the Chicago Tribune noted that the song's "countrified ache" represented that part of Charles' career.

[78] While reviewing ...Featuring, Jonathan Keefe of Slant Magazine wrote that the duet was a "more staid and less compelling recording" on the album.

For the week ending September 18, 2004, Genius Loves Company sold 202,000 copies, ranking second on the US Billboard 200 chart and becoming Charles' highest-charting album in over 40 years.

[87][88] During the week the album was released, the song debuted on the US Billboard Hot Digital Tracks chart at number 26.

[92] "Here We Go Again" entered the US Billboard Bubbling Under Hot 100 chart at number five in the issue dated (for the week ending) February 26, 2005.

[116][117] Their collaboration was favorably reviewed, and McEntire was said to reinvigorate this country standard by Nathalie Baret of ABQ Journal.

[125][126] Willie Nelson and Wynton Marsalis, along with Norah Jones, performed two concerts at Lincoln Center's Rose Theatre on February 9 and 10, 2009.

[127][128] The vocals on "Here We Go Again" were performed by Jones and Nelson, while instrumental support was provided by Marsalis (trumpet), Dan Nimmer (piano), Mickey Raphael (harmonica), Walter Blanding (tenor saxophone), Carlos Henriquez (bass) and Ali Jackson (drums and percussion).

[86] BBC music reviewer Bill Tilland noted that Jones added her usual "style and panache" to this performance.

[129] At one concert performance, The New York Times critic Nate Chinen felt the song sounded unrehearsed.

[130] Although critique of this track is sparse, Pop Matters's Will Layman notes that the album reveals "how decisive and strong Jones sounds while singing with a truly legitimate jazz group" and how Nelson predictably "breezes through his tunes with cavalier grace".

[134] Ralph Novak, Lisa Shea, Eric Levin, and Craig Tomashoff of People said the album represents the most straightforward style of singing.