After playing minor roles in several provincial engagements, he began performing leading characters as Cardinal Richelieu, Sir Edward Mortimer, Claude Melnotte, and Young Norval.

Vezin followed up with other successful showings, such as The Turn of the Tide by F. C. Burnand (1869), Son of the Soil (1872); As You Like It (1875); and W. S. Gilbert's Dan'l Druce, Blacksmith, which ran for one hundred and nineteen performances at the Haymarket Theatre (1876, also a revival in 1884);[4] He acted with Charles Fechter, Samuel Phelps, Henry Irving, and in 1878 played Dr. Primrose alongside actress Ellen Terry in Wills' Olivia, Vicar of Wakefield (1878),[5] a highly successful adaptation of Oliver Goldsmith's novel, The Vicar of Wakefield (1766).

For this, George Grossmith gave a sketch, and play scenes featured Gerald du Maurier, Herbert Beerbohm Tree and Cyril Maude, among others.

[11] In his declining years, Vezin appear infrequently on the stage, rather spending most of his time giving lessons to aspiring thespians, including the actors Herbert Beerbohm Tree, Baliol Holloway and Frank Benson as well as the actress Mary Mannering.

His last stage role was Old Rowley in Tree's production of playwright Richard Sheridan's The School for Scandal at His Majesty's Theatre in Scotland, in April 1909.

He had been active on the British stage for nearly sixty years, and had been a resident of London, where he died at his home, 10 Lancaster Place, Strand, on June 12, 1910.