Sophia Hermine was the second child of Catharina Gertrudis, née Peltzer, and the dyer and knife maker Johann Peter Jacob Peipers.
The couple's two sons and three daughters, who were born between 1802 and 1811, included the later landscape and vedute painter Friedrich Eugen Peipers.
In addition to watercolours, Hermine Stilke primarily created illustrations, initials, and other elements of decorative prints.
Her works found their way into numerous albums, collections of poems, sayings and songs, travelogues, and luxury volumes as book decorations.
With Alwine Schroedter, wife of painter Adolf Schrödter, she is considered one of the most important German artists of the 19th century.