Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor)[2] is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.

[3][4] VP16 is a strong transactivator[5] and is often used in Y2H systems as the activation domain of the system.

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