[4] In 2000, Peirce served at the Securities and Exchange Commission, first as a staff attorney in the Division of Investment Management from 2000 to 2004 and then as counsel to Commissioner Paul S. Atkins from 2004 to 2008.

[6] Between 2012 and 2017, Peirce was a senior research fellow and the director of the Financial Markets Working Group at the Mercatus Center at George Mason University[7] where she also teaches as an adjunct professor at the Antonin Scalia Law School.

Democrats on the Senate Banking Committee attempted to block her nomination because she declined to fully commit to requiring corporations to publicly disclose political donations.

[10] On July 18, 2017, the White House announced that President Donald Trump would nominate Peirce as a Commissioner of the SEC for the remainder of a five-year term expiring on June 5, 2020.

[17] In 2016, a book she co-edited entitled Reframing Financial Regulation: Enhancing Stability and Protecting Consumers was published by the Mercatus Center.

In January 2017, she spoke at the American Economic Association in Chicago, where she discussed reforms of the role of financial regulators[21] a topic she had previously raised in a video by the Mercatus Center in 2015.