After graduating, he returned to Nuremberg as a follower of Luther and participated in local politics; rising rapidly.
In 1525, he was a participant in the Nürnberger Religionsgespräch [de], a series of six discussions between old believers and Evangelicals, led by Christoph von Scheurl.
The following year, together with Melanchthon and Lazarus Spengler, he helped establish Germany's first humanist school, the Melanchthon-Gymnasium Nürnberg [de].
In 1536, he was involved with the Konvent in Schmalkalden [de], which produced the Schmalkald Articles, an ecumenical document signed by Luther in 1537.
However, in 1526, he married Sybilla Dichtlin (died 1567), the daughter of Bernhard Dichtel, a pfleger (castle manager) in Starnberg; originally from Tutzing.