The Higashihiroshima-Kure Expressway (東広島呉自動車道, Higashihiroshima-Kure Jidōsha-dō) is an national expressway in the southern part of Hiroshima Prefecture.

The route connects the city of Higashihiroshima and the San'yō Expressway to the city of Kure on the coast of the Seto Inland Sea.

It is owned and operated primarily by the Ministry of Land, Infrastructure, Transport and Tourism (MLIT).

The route is signed E75 under MLIT's "2016 Proposal for Realization of Expressway Numbering.

"[1] The Higashihiroshima-Kure Expressway was built to relieve traffic along Japan National Route 375 between the cities of Higashihiroshima and Kure.