Highgate Center is the primary village and a census-designated place (CDP) in the town of Highgate, Franklin County, Vermont, United States.

The CDP is in northwestern Franklin County, in the south-central part of the town of Highgate.

It sits on the north side of the Missisquoi River, a west-flowing tributary of Lake Champlain, where the river passes over Highgate Falls.

Vermont Route 78 (Franklin Street) passes through the center of the village, leading southeast 6 miles (10 km) to Vermont Route 105 at Sheldon Junction and southwest 4 miles (6 km) to Swanton.

Vermont Route 207 also passes through the village, leading south 9 miles (14 km) to St. Albans and northeast 6 miles (10 km) to the Canadian border at Morses Line.