The title sounds like it might have come from a weather report, although "Highs" intends to mean "the best" (and is also an apparent drug reference), while the recordings on these albums were originally released in the mid-1960s.
The individual albums in the Pebbles series include records from throughout the US, along with a few from Canada and other countries.
As a result, many of the albums evidence a particular regional "sound" in the musical scene in that part of the country.
The areas that are documented in the Highs in the Mid-Sixties series cover a large portion of the nation, particularly between the Pacific Coast and the Mississippi River.
However, the series is hardly comprehensive; among the notable omissions are New York, along with the rest of the Northeast, plus San Francisco (although the last album among the CDs in the Pebbles series, Pebbles, Volume 11 covers northern California).