Hightower previously served the rest of Arcola,[6] sections of master-planned community of Sienna Plantation,[7] and the unincorporated area of Juliff.

"[13] Pavlos Karnezis, a 12th grade honors student, was sent to jail and later expelled from school for bringing a knife to class in November 2005.

"[12] Hightower is adjacent to the District owned Hall Stadium and Hopson Field House, resulting in a decrease of transportation for football games.

In UIL terms, they are in district 6A-20, alongside Austin, Bush, Clements, Dulles, Kempner, Ridge Point, and Travis High Schools, all of which are in Fort Bend ISD.

[18] In 2006, Hightower qualified 16 students for the National HOSA competition in Anaheim, of which all 16 placed top 4 or higher in their respective categories.

In 2008, Hightower High School qualified 38 students for the National HOSA Leadership Conference in Dallas, Texas.

Team members Jonathan Vo and Matthew Lei were also named to the mastery level of the Kaiser Permanente Medical Current Events Roster based on their placement in the top 10 in the United States.

[20] In 2010, Hightower High School qualified 34 students for the National HOSA Leadership Conference in Orlando, Florida.

[21] Hightower High School originally had a Robotics team, which has placed in several local and statewide competitions.

In 2019, Hightower High School qualified 9 students for the National HOSA Leadership Conference in Orlando, Florida.

The group consisting of Saeed Ahmed, Gayathry James, Gisela Mathew, Yasamine Shehni, Susan Varghese, and Natasha Verghese earned second place in the Secondary-Division event of Public Health Emergency Preparedness.

[23][24] Contender Isabella Gándara received a 'Highest Overall Score' award in the Secondary-Division of the Health Care Issues Exam.