[5] Jackie Quiñones (Monica Raymund) is a National Marine Fisheries Service Agent in Provincetown, Massachusetts who abuses alcohol and drugs.

She finds the body of a murdered woman, which launches an investigation by Detectives Alan Saintille (Dohn Norwood) and Ray Abruzzo (James Badge Dale) into Cape Cod organized crime and the local opioid epidemic.

The series was created by Rebecca Cutter, with Gary Lennon as showrunner and both serving executive producers alongside Jerry Bruckheimer, Jonathan Littman, and KristieAnne Reed.

[7] On December 16, 2020, Crystal Lee Brown, Cecil Blutcher, Carlos Gomez, and Barbara Weetman joined the cast in recurring capacities for the second season.

[8] On June 15, 2022, Garret Dillahunt, Jeanine Serralles, Kaya Rosenthal, Michael Drayer, Ellie Barone, and Taja V. Simpson were cast in recurring roles for the third season.

The website's critical consensus reads, "Monica Raymund's charms rise above any formulaic tendencies in Hightown's highly entertaining first season.