Popularly known as the Riyadh–Qassim Expressway, Highway 65 connects Howtat Bani Tamim to Qurayyat and further to the Al Hadithah border with Jordan, while providing connections to or passing through Riyadh, Majma'ah, al-Ghat, Zulfi, Buraidah, 'Unaizah, ar-Rass, Ha'il, Daumat al-Jandal, Sakakah and other smaller villages and towns.

Starting at Howtat Bani Tamim south of Riyadh, the highway runs in the southeast–northwest direction and ends at the Al Hadithah/Omari border with Jordan near Qurayyat.

It is also part of the Arab Mashreq International Road Network and carries Route 35M Riyadh–Buraidah–Ha'il–Sakakah–Al Hadithah/Omari–Azraq–Amman through the central Arabian Peninsula.

There are numerous rest areas along the highway, with some being limited to the most basic of amenities featuring a petrol station and cafe, with others including restaurants, hotels and fast-food outlets.

Almost all have a masjid, with recent regulations declaring the travel time between rest areas be no longer than 60 minutes.