The Hill–Physick–Keith House stands in the southern part of Philadelphia's Center City, freestanding on a parcel bounded by Delancey, Cypress, and South 4th Streets.

It is decorated in with Federal and Empire style furnishings, including some that belonged to its most famous owner, Philip Syng Physick.

[3] Physick, born in Philadelphia, was trained in London and Edinburgh in surgery, a skill which he brought back to his hometown.

He taught surgery and anatomy at the University of Pennsylvania, training an entire generation of new surgeons in the arts he had learned.

In the late 1960s, publisher Walter Annenberg restored the house and then donated it to the Philadelphia Society for the Preservation of Landmarks.