Hillsborough Historic District is a national historic district located at Hillsborough, Orange County, North Carolina.

The district includes buildings dating to the late-18th and early-20th century and includes notable examples of Federal, Greek Revival, and Italianate style architecture.

Located in the district are the separately listed Burwell School, Eagle Lodge, Hazel-Nash House, Heartsease, Montrose, Nash Law Office, Nash-Hooper House, Old Orange County Courthouse, Poplar Hill, Ruffin-Roulhac House, Sans Souci, and St. Matthew's Episcopal Church and Churchyard.

[2][3] It was listed on the National Register of Historic Places (NRHP) in 1973.

This article about a property in Orange County, North Carolina on the National Register of Historic Places is a stub.