Hinsdale South High School, or HSHS, and locally referred to as "South," is a public four-year high school located at the corner of 75th Street and Clarendon Hills Road in Darien, Illinois, a southwestern suburb of Chicago, Illinois, in the United States.

The South campus draws its students from the nearby communities of Darien (east of Cass Ave.), and portions of Burr Ridge, Willowbrook, and Westmont.

Hinsdale South is home to the LaGrange Area Department of Special Education (LADSE) Deaf and Hard of Hearing program.

Also, students at Hinsdale South are allowed the option of bringing a computer laptop or personal digital assistant for note taking and word processing.

The school sponsors interscholastic teams for young men and women in: basketball, bowling, cross country, golf, gymnastics, soccer, swimming & diving, tennis, track & field, volleyball, and water polo.

[13] The following teams won their respective IHSA sponsored state championship tournament or meet: Hinsdale South engages in two rivalries in football.

[16] The winner of the annual game with Downers Grove South High School is awarded the Rebel Cannon trophy.