She worked for a decade in Phoenix, Arizona, area emergency departments, is a cancer research advocate,[1] and serves on the board of directors of the Maricopa Health Foundation.

[14] In August 2017, Tipirneni, a Democrat, announced her candidacy for the congressional seat representing the 8th district then held by Republican Trent Franks.

[15] She later entered the race in the special election for Arizona's 8th congressional district, following Franks' resignation amidst numerous claims of sexual misbehavior with female staffers.

[5][9] Tipirneni has garnered some national support including endorsements from End Citizens United and Gabby Giffords, the former congresswoman from Arizona.

[26][27] Her campaign has focused on issues related to health care, education, and retirement security, and emphasizes her "data-driven approach" to public policy.

[31] Tipirneni also agrees that Americans have the Second Amendment right to purchase firearms legally in order "to protect their homes, themselves and their families, and for hunting and sport".