Hirut Meshesha gained her first international experience at the 2017 IAAF World U18 Championships held in Nairobi, Kenya, where she won the bronze medal in the girls' 800 metres.

She then went to Argentina for 2018 Summer Youth Olympics in Buenos Aires and took bronze in the girls' 800m event In April 2019, she competed at the African U18 and U20 Championships, which were held in Abidjan, Ivory Coast, and won the silver medal at 800m in the under-20 women category.

In August, Meshesha represented Ethiopia at the 2019 African Games held in Rabat, Morocco and won the gold medal in the 800m event.

[1][2][3] She earned the bronze medal for the women's 1500 metres at the 2022 World Indoor Championships held in Belgrade, Serbia.

Her compatriot Gudaf Tsegay led and Ethiopian medals sweep as Axumawit Embaye came second.