Furthermore, the Museum of San Marco with masterpieces by Fra Angelico, the Accademia Gallery which houses among other works the David by Michelangelo (1501–1504), and the Piazza della Santissima Annunziata with the Loggia of the Innocenti by Filippo Brunelleschi.

Heading south from the Duomo there is the political and cultural center of Florence with Palazzo Vecchio and the Uffizi Gallery nearby, near which are the Bargello Museum and the Basilica of the Holy Cross.

Still in Oltrarno, there are the Basilica of the Holy Spirit by Filippo Brunelleschi and the Church of Santa Maria del Carmine, with frescoes by Masolino, Masaccio and Filippino Lippi.

In the area west of the Duomo is situated the imposing palace Palazzo Strozzi (home of major exhibitions and cultural institutions) and the Basilica of Santa Maria Novella, with the facade designed by Leon Battista Alberti.

The center of Florence, with its hundreds of business activities is a paradise for shopping and entertainment: elegant boutiques, historic cafes, the lively street markets, as well as hosting numerous nightclubs, discos, American-bar and meeting places for a drink (the famous Negroni cocktail was born here).