Each episode is divided into different segments concerning a different "lost" item or artifact from history.

Each segment runs around 7 minutes and in this time we learn the history, of several famous lost artifacts such as the flags from the Battle of Iwo Jima, and other not-so-famous artifacts like the first TV dinner tray.

The series is based on the book "Lucy's Bones, Sacred Stones and Einstein's Brain" by Harvey Rachlin.

The History Channel continued to air the show in reruns every Sunday morning at 6:00 and 6:30 AM for many years.

The show originally ran in an hour format featuring six items in each episode.