The film stars Shepard and Kristen Bell, with Kristin Chenoweth, Tom Arnold, and Bradley Cooper, and follows a man who has been placed in Federal Witness Protection going on the run with his girlfriend to escape a mobster.

Charlie, unable to return to Los Angeles since enrolling in Witness Protection, insists Annie take the interview without him.

Instead, Annie returns to work to beg to keep her job, but Charlie picks her up in his souped-up, restored Lincoln Continental to take her to the interview.

Gil discovers Charlie is a former getaway driver who testified in an unsuccessful case against his fellow bank robbers.

Alex sees Gil's message and gathers his fellow bank robbers Neve and Allen to find him.

His father mentions his Class 1 Off-Road racing vehicle, and attacks Alex’s crew as Charlie and Annie escape in the racer, just as Gil, Randy, Terry and Angela arrive.

Charlie and Annie reconcile and arrive in time for her interview; He offers to spend the rest of his life with her, and she accepts.

Osterman reveals Debby is his sister, and Annie sympathizes with him, earning his approval and an immediate job offer, which she accepts.

[citation needed] The final scene was filmed in front of Oviatt Library, California State University, Northridge.

The website's critical consensus reads, "Though Hit & Run has some surprisingly oft-kilter [sic] filmmaking, the action doesn't add to much and the writing's a bit smug.