After graduating, Ho joined a Chinese shipping firm in Haiphong as a clerk and later worked as a translator at the Registrar-General's department.

[6] In 1921, Ho and fellow Legislative Councilor Lau Chu Pak established the Society for the Protection of the Mui Tsai in defense of the mui-tsai system, a form of child slavery with the support of Chinese community leaders like Ts'o Seen Wan, Chow Shou-son and Ho Kom-tong.

[7] He served as vice-president of the Ellis Kadoorie Chinese School Society and member of the Court of the University of Hong Kong.

[8] Ho Fook's father was a man of Jewish Dutch ancestry named Charles Henri Maurice Bosman (1839–1892)[1][2][3] and his mother was Madame Sze, a local woman of Bao'an (present-day Shenzhen) heritage.

His brothers Sir Robert Hotung and half-brother Ho Kom-tong (same mother; father Kwok Hing-yin (郭興賢)) were also prominent social figures in Hong Kong.

Sassoon & Co. Ho Wing, another son of him who was adopted by Robert Hotung was also the compradore of the Hongkong and Shanghai Banking Corporation.