Born in Macau to his parents from Jinhua, Zhejiang, Ho studied at Pooi To Middle School [zh].

[2] Ho served as a member of the Chinese People's Political Consultative Conference of Zhejiang Province from 1978 to 1998.

[3] On 18 April 2019, Ho announced his intention to run for election in August as Macau's chief executive.

[4] Ho was elected as chief executive on 25 August 2019,[5] and was subsequently appointed by Li Keqiang, Premier of China.

[7] On 21 August 2024, Ho announced that he would not seek another term as chief executive in elections scheduled for October, citing ill health.