Towns are marked in bold: Archlebov - Blatnice pod Svatým Antonínkem - Blatnička - Bukovany - Bzenec - Čejč - Čejkovice - Čeložnice - Dambořice - Dolní Bojanovice - Domanín - Dražůvky - Dubňany - Hodonín - Hovorany - Hroznová Lhota - Hrubá Vrbka - Hýsly - Javorník - Ježov - Josefov - Karlín - Kelčany - Kněždub - Kostelec - Kozojídky - Kuželov - Kyjov - Labuty - Lipov - Louka - Lovčice - Lužice - Malá Vrbka - Mikulčice - Milotice - Mouchnice - Moravany - Moravský Písek - Mutěnice - Násedlovice - Nechvalín - Nenkovice - Nová Lhota - Nový Poddvorov - Ostrovánky - Petrov - Prušánky - Radějov - Ratíškovice - Rohatec - Šardice - Skalka - Skoronice - Sobůlky - Starý Poddvorov - Stavěšice - Strážnice - Strážovice - Sudoměřice - Suchov - Svatobořice-Mistřín - Syrovín - Tasov - Těmice - Terezín - Tvarožná Lhota - Uhřice - Vacenovice - Velká nad Veličkou - Veselí nad Moravou - Věteřov - Vlkoš - Vnorovy - Vracov - Vřesovice - Žádovice - Žarošice - Ždánice - Želetice - Žeravice - Žeraviny Hodonín District borders Slovakia in the south.

A large part consists of the lowland, which belongs to the warmest and driest areas in the country.

The territory extends into seven geomorphological mesoregions: Lower Morava Valley (southwest and centre), Kyjov Hills (a strip from west to east), Ždánice Forest (northwest), Chřiby (small part in the northeast), Vizovice Highlands (east), White Carpathians (southeast), and Chvojnice Hills (a negligible area along the Czech-Slovak border).

The highest point of the district is a contour line on the slopes of the mountain Durda in Nová Lhota with an elevation of 838 m (2,749 ft).

Overall, the territory of the district is poor in bodies of water, but there is a numerous system of fishponds on the Kyjovka River.