Until recently, Ramon Hofileña, one of the children and heirs, resided in this ancestral house and personally toured guests who visited his abode.

[6] In 1989, the BBC television series "Far Eastern Cookery" shot some of its scenes in the Hofileña Ancestral House when it featured Ilonggo delicacies.

The house was also used as a setting by a Canadian movie company for a documentary on the sugar industry in Negros, which was shown at the Toronto Film Festival in 2011.

The grand staircase, which came from Gilda Hofileña's ancestral house, is made of ironwood, or "balayong", which is not susceptible to termites and impenetrable by nails.

[8] The dining room, or comedor, features cabinets of antique pieces, such as Chinese porcelain wares and jars from the Ming dynasty.

The second floor is a gallery of over 1,000 art treasures, featuring the paintings and sketches of national artists Juan Luna, Felix Resurrecion Hidalgo, Fernando Amorsolo, Ang Kiukok, Vicente Manansala, Hernando R. Ocampo, and BenCab.

Alongside these master's works is a sketch made by the young Jose Rizal, the national hero, and a painting by Spanish artist Francisco Goya.

[4] On July 5, 2024, the museum announced the theft of a 1936 painting by Fernando Amorsolo titled Mango Harvesters, which hung from the second floor of the house and previously belonged to Ramon Hofileña.

[11] The painting was recovered in Quezon City on July 12 by the National Bureau of Investigation, which arrested two people on suspicion of trying to sell the artwork for P3.5 million.