The street dates back to Roman times, when it was the city's Cardo Maximus, running parallel to the River Rhine.
Over the centuries, the street kept its central functions, but changed names numerous times and developed several distinct stretches.
During the Early Middle Ages it was first called "strata lapidea" or "Steinweg", (meaning Stone Street), given that for a long time it remained an example of a Roman road.
Hohe Straße's section North of the city hall became center of the newly established University of Cologne in the year 1388.
Among today's landmarks on Hohe Straße are shopping passage of Cologne chocolatier Stollwerck and flagship store Leonhard Tietz of Galeria Kaufhof.