It has been represented in the House of Commons of the Parliament of the United Kingdom since 2015 by Sir Keir Starmer, the Prime Minister since 2024 and Leader of the Labour Party since 2020.

[2][n 2] The seat of Holborn and St Pancras as drawn in 2010 is composed of all but a small western portion of the London Borough of Camden and extends from most of Covent Garden and Bloomsbury in the heart of the West End of London through other areas of the NW1 postal district, north, and in elevation terms upwards through fashionable and economically diverse Camden Town to the affluent suburb of Highgate in a long strip.

The southern part of the seat includes the University of London and several teaching hospitals, so the constituency has a large student population.

[3] During the 20th century, the Bloomsbury, Holborn, Covent Garden, and Highgate wards overwhelmingly elected Conservative councillors.

The constituency has contained the following wards of the London Borough of Camden: Bloomsbury, Brunswick, Camden, Castlehaven, Caversham, Chalk Farm, Gospel Oak, Grafton, Holborn, King's Cross, Regent's Park, St John's, St Pancras, and Somers Town.