Holcomb /ˈhɔːkəm/ HAW-kəm is a city in Dunklin County, Missouri, United States.

The St. Francis River and the Missouri-Arkansas state line pass just to the west.

According to the United States Census Bureau, the city has a total area of 0.58 square miles (1.50 km2), all land.

There were 279 housing units at an average density of 481.0 per square mile (185.7/km2).

27.4% of all households were made up of individuals, and 13.7% had someone living alone who was 65 years of age or older.

There were 302 housing units at an average density of 494.7 per square mile (191.0/km2).

26.8% of all households were made up of individuals, and 15.0% had someone living alone who was 65 years of age or older.