It succeeded the Woodville Plant as South Australia's main assembly facility.

Elizabeth became the last remaining Holden plant in 1989 after Dandenong closed.

In 2006, the plant underwent a redesign known to have cost more than $1 Billion (AUD), this budget was shared with Holdens development of the General Motors Zeta platform, of which's introduction in the Fourth Generation VE Commodore led to the retooling of the facility.

[3][4] Australian production of the Cruze ceased in 2016, leaving the Commodore and its ute derivative to be the only vehicles being produced at the plant.

[5] The last vehicle, a 'Red Hot' VF Holden Commodore SS V Redline (which is currently in the collection at the National Motor Museum, Birdwood) rolled off the line on October 20, 2017.