It was originally opened in February 1911 by the Chicago, Burlington and Quincy Railroad as the CB&Q Holdrege Depot, and the depot has been listed on the National Register of Historic Places since February 21, 1997.

Passenger service to the station ended in July 2020, owing to Americans with Disabilities Act concerns not being addressed by the building's owner.

Amtrak constructed a new platform 63 yards (58 m) to the east and resumed service that October.

At Holdrege, the railroad installed a new heated shelter, new signage, LED lighting, wheelchair lifts with an enclosure.

This article about a property in Nebraska on the National Register of Historic Places is a stub.