A little-known starlet, Raquel Welch, was cast during the first season as the "Billboard Girl", who placed the names of the acts on a placard (similar to that of a vaudeville house).

Among the show's many performers and hosts were Bing Crosby (who hosted the series' first and final episodes and had the most appearances as guest host: 31 in all, including his family on several of the annual Christmas shows), Dean Martin, Liberace, Frank Sinatra, Milton Berle, Sammy Davis Jr., Sid Caesar, Peter Lawford, The Rolling Stones, Groucho Marx, Joan Crawford, Bette Davis, Tony Bennett, Judy Garland, Jimmy Durante, The Supremes, Ginger Rogers, The Temptations, Dusty Springfield, Phyllis Diller, and Elizabeth Montgomery.

He enjoyed the gig enough to subsequently agree to star in his own variety series, The Dean Martin Show, which premiered on NBC in 1965 and ran for nine years.)

At the time, they were relatively unknown in the U.S., and a second song recorded in the same session, Buddy Holly's "Not Fade Away", was not shown until the second episode of the second season, hosted by Ed Wynn, that aired on September 26, 1964.

The February 25, 1967, edition featured the American television debut of the Beatles' music videos for "Penny Lane" and "Strawberry Fields Forever", introduced by guest host Van Johnson.

The facility was the first color studio renovated by ABC Television on the West Coast, converted during The Hollywood Palace's summer hiatus.

Exposure of the Knickerbocker Hotel's electric sign atop the rear building, behind the Palace Theater, was a unique advertisement shown in every parking lot act.

For most of its television run, with a lead-in of The Lawrence Welk Show at 8:30 pm, at 9:30, The Hollywood Palace enjoyed consistently respectable ratings, although it never made the top 30 programs.

The same year, it was nominated for a variety series, arranging (Joe Lipman), costume design (Ed Smith), and conducting (Mitchell Ayres).