The school is known for its academic enhancement program, which features courses focused on assisting students who have difficulty in core subjects.

Holy Cross High School offers a wide range of activities for students.

Teams of 15 students are chosen to attend one international mock government conference per year, typically hosted by a premier university.

Other popular activities include art club, football, soccer, basketball, volleyball, golf, bowling, softball, track and field, cross country, swimming, intramural basketball, tennis, academic team, school paper, drama club, choir, Students Against Destructive Decisions (SADD), rosary club, and baseball.

Among the major sports, soccer, basketball and volleyball have won the Kentucky "All-A Tournament" in recent years.